Vanderbilt University · PhysiologyMembrane Transport Research Lab
Hassane S Mchaourab · Nashville, Tennessee
Research Focus
Dr. Hassane S Mchaourab's lab focuses on understanding how certain proteins transport substances across cell membranes, particularly in relation to drug resistance in bacterial infections and cancer. By examining the structural movements of these proteins, known as transporters, the lab aims to uncover how they function and how they can be targeted to improve treatment outcomes. The research combines state-of-the-art techniques like cryo-electron microscopy and machine learning to shed light on these critical biological processes.
active transportersdrug resistancemembrane proteinscryoelectron microscopyATP hydrolysismultidrug resistancesubstrate bindingmachine learningprotein dynamicsbacterial defense mechanisms
Research Aims
5AIM 01Illuminate the structural dynamics of transporter proteins in cell membranes.
AIM 02Understand how energy conversion occurs in multidrug transporters.
AIM 03Define interactions between transporters and lipids to reveal energy landscapes.
AIM 04Investigate the coupling of ions and substrates in efflux mechanisms.
AIM 05Develop strategies to inhibit transporters involved in drug resistance.
Skills the Lab Values
cryoelectron microscopyEPR spectroscopyprotein purificationmolecular biology techniquescell membrane studiesbioinformaticsmachine learning applicationsstructural biologyspectral analysis
Output against the department
Publications278top 19% of dept.55th of 286
this lab
most publishedleast published
Citations12ktop 25% of dept.71st of 286
this lab
most citedleast cited
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