University of New Mexico-Main Campus · BiologyThe Hypoxia Vascular Lab
Thomas C Resta · Albuquerque, New Mexico
Research Focus
Dr. Thomas C. Resta's lab focuses on understanding how chronic hypoxia affects vascular health, specifically in the context of pulmonary hypertension. The research examines the role of oxidative signaling mechanisms that change how cells in the lungs respond to various stimuli. By investigating how changes in cholesterol and reactive oxygen species contribute to vascular dysfunction, the lab aims to uncover new treatment strategies for chronic lung diseases.
pulmonary hypertensionchronic hypoxiaoxidant signalingvascular dysfunctioncholesterol homeostasis
Research Aims
3AIM 01Investigate how chronic hypoxia affects cholesterol levels in pulmonary arterial smooth muscle cells.
AIM 02Elucidate the signaling pathways that enhance reactive oxygen species generation and vasoconstriction in response to chronic hypoxia.
AIM 03Examine the role of Cav1 and mitochondrial reactive oxygen species in the development of pulmonary hypertension.
Skills the Lab Values
cell cultureanimal modelsfluorescence microscopyWestern blotRNA sequencing
Output against the department
Publications161top 42% of dept.430th of 1,033
this lab
most publishedleast published
Citations3.5kbottom 26% of dept.760th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.