New York University · NeuroscienceMultiple System Atrophy Research Lab
Un Jung Kang · New York, New York
Research Focus
Un Jung Kang's research lab focuses on understanding multiple system atrophy (MSA), a rare and fatal neurodegenerative disease. The lab uses advanced single nucleus RNA sequencing techniques to investigate how different brain cells are affected by MSA. By analyzing gene expression changes in postmortem brain tissue from MSA patients, the lab aims to uncover mechanisms leading to neuronal death and explore potential therapeutic targets.
multiple system atrophyneurodegenerationsingle nucleus RNA sequencinggene expressionoligodendrocytesalpha-synucleinpathologyneural tissue
Research Aims
3AIM 01Generate transcriptomic profiles of brain cells from MSA patients using snRNA-seq.
AIM 02Identify transcriptional changes in oligodendrocytes associated with MSA pathology.
AIM 03Investigate whether increased alpha-synuclein expression leads to myelin integrity loss in oligodendrocytes.
Skills the Lab Values
single nucleus RNA sequencingimmunohistochemistrymultiplexed fluorescence in situ hybridizationdata analysisbioinformaticscell culturetissue processingRNA extractionanimal modelspathological examination
Output against the department
Publications195top 38% of dept.254th of 671
this lab
most publishedleast published
Citations13ktop 31% of dept.205th of 671
this lab
most citedleast cited
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