University of Louisville · BiochemistryThe PCB Metabolism Lab
Carolyn M. Klinge · Louisville, Kentucky
Research Focus
Dr. Carolyn Klinge's lab at the University of Louisville investigates how environmental contaminants, specifically polychlorinated biphenyls (PCBs), affect liver health and metabolism. By examining RNA modifications, particularly N(6)-methyladenosine (m6A), the lab aims to understand their role in metabolic diseases, especially metabolic dysfunction-associated steatotic liver disease (MASLD) and how factors like diet and sex differences influence these processes. Through innovative techniques, the research seeks potential therapeutic targets for improving liver health in the face of environmental exposure.
RNA modificationsenvironmental contaminantsmetabolic diseasesliver healthapolipoprotein regulationsex differencesdietary impacts
Research Aims
3AIM 01Determine the impact of PCB exposures on m6A modification of the Apob transcript.
AIM 02Investigate how diet and sex modify m6A marks in lipoprotein transcripts.
AIM 03Evaluate m6A-induced alternative splicing in livers of mice exposed to PCB and high-fat diets.
Skills the Lab Values
RNA immunoprecipitationmRNA sequencingcell culturemouse modelsmolecular cloningsequencing analysisbiochemical assaysWestern blottingdata analysisgene expression studies
Output against the department
Publications246top 30% of dept.121st of 402
this lab
most publishedleast published
Citations11ktop 45% of dept.181st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.