University of Virginia-Main Campus · Microbiology & ImmunologyCliffe Virology Lab
Anna Ruth Cliffe · Charlottesville, Virginia
Research Focus
Dr. Anna Ruth Cliffe's lab at the University of Virginia focuses on understanding how the Herpes Simplex Virus (HSV) establishes and maintains latency in neurons. This work investigates the role of specific proteins, particularly ATRX, in silencing the viral genome to prevent reactivation, which can lead to disease. The lab aims to uncover the molecular mechanisms that contribute to HSV latency and explore potential therapeutic strategies to mitigate reactivation of the virus.
Herpes Simplex VirusHSV latencyneuronal developmentATRXheterochromatinepigeneticsviral reactivationgene silencingtherapeuticschromatin modification
Research Aims
3AIM 01Determine the role of ATRX in promoting HSV latency.
AIM 02Investigate how ATRX prevents HSV reactivation during stress.
AIM 03Explore the impact of H2AK119ub1 in LAT and its role in establishing latency.
Skills the Lab Values
animal modelsin vitro culturechromatin immunoprecipitationepigenetic assayshigh-resolution imagingWestern blottingRNA interferencePCRdata analysisflow cytometry
Output against the department
Publications58bottom 15% of dept.414th of 486
this lab
most publishedleast published
Citations2.0kbottom 13% of dept.423rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.