University of California-San Francisco · BiochemistryHomeostatic Plasticity Research Lab
Graeme W Davis · San Francisco, California
Research Focus
Dr. Graeme W. Davis's lab at UCSF studies homeostatic plasticity, which helps neurons stabilize their function in response to changes. Their research focuses on the mechanisms linking this plasticity to neurodevelopmental disorders, mental health, and age-related declines in neuromuscular function. By investigating these connections, the lab aims to explore new therapeutic strategies for conditions like Jordan's Syndrome and other neurodegenerative diseases.
homeostatic plasticityneurodevelopmental disordersmental healthagingneuromuscular function
Research Aims
5AIM 01Investigate the role of homeostatic plasticity in Jordan's Syndrome and other neurodevelopmental disorders.
AIM 02Explore how homeostatic neuroprotection can mitigate age-related neuromuscular decline in mice.
AIM 03Characterize genetic pathways related to mental health disorders through homeostatic maintenance.
AIM 04Determine the mechanisms of presynaptic homeostatic plasticity in model organisms and their relevance to human disease.
AIM 05Develop therapeutic approaches that harness homeostatic signaling for neurological disorders.
Skills the Lab Values
mouse modelsgenetic screeningmolecular biology techniquesbiochemical assayselectrophysiologyimmunohistochemistrydata analysisDrosophila modelsWestern blotCRISPR
Output against the department
Publications134bottom 38% of dept.249th of 402
this lab
most publishedleast published
Citations12ktop 43% of dept.173rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.