University of Pittsburgh-Pittsburgh Campus · PharmacologyNanoparticle Cancer Therapeutics Lab
Song Li · Pittsburgh, Pennsylvania
Research Focus
The research lab led by Song Li at the University of Pittsburgh focuses on developing novel therapies for metastatic breast and colon cancers. They are working on advanced drug delivery systems using nanoparticles to combine RNA interference with classic chemotherapy, aiming to improve treatment effectiveness and overcome drug resistance in cancer patients. The lab's research has potential implications for enhancing immune responses against tumors.
nanoparticlesbreast cancercolon cancerRNA interferencechemotherapyimmunotherapydrug resistancecombination therapy
Research Aims
3AIM 01Develop improved nanocarrier systems for delivering chemotherapeutics and siRNA to tumors.
AIM 02Investigate the targeting efficiency and biodistribution of nanocarriers in cancer therapy.
AIM 03Examine the therapeutic efficacy and mechanisms of combination therapies in preclinical models.
Skills the Lab Values
nanoparticle formulationcell culturein vivo mouse modelsRNA sequencinggene knockdown (siRNA)immunohistochemistrypharmacokinetics studiesdata analysis using R or Pythontumor microenvironment analysis