University of North Carolina at Chapel Hill · GeneticsDuronio Chromatin Lab
Robert J Duronio · Chapel Hill, North Carolina
Research Focus
Dr. Robert J. Duronio's lab focuses on understanding how the organization and assembly of chromatin affects genome replication during animal development. The research investigates the roles of histone proteins and their modifications in regulating the fidelity of DNA replication, which is crucial for preventing diseases like cancer. By using Drosophila as a model organism, the lab employs advanced genetic and molecular techniques to uncover the mechanisms behind these processes.
chromatinDNA replicationhistone proteinsepigeneticsDrosophila melanogastergene expressioncell cyclecancer researchmolecular biology
Research Aims
4AIM 01Investigate how chromatin assembly influences DNA replication during development.
AIM 02Analyze the role of Histone Locus Bodies in histone mRNA biosynthesis.
AIM 03Explore the impacts of histone modifications on chromatin organization and genome function.
AIM 04Utilize genetic tools in Drosophila to manipulate histone sequences and assess consequences for replication fidelity.
Skills the Lab Values
Drosophila geneticscell culturenext generation sequencingbiochemical assaysmolecular cloninggene expression analysisimaging techniqueshistone modification assaysprotein purification
Output against the department
Publications182top 46% of dept.118th of 259
this lab
most publishedleast published
Citations9.1kbottom 47% of dept.138th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.