Columbia University in the City of New York · ChemistrySynthetic Yeast Therapeutics Lab
Virginia W Cornish · New York, New York
Research Focus
Dr. Virginia W. Cornish's lab at Columbia University focuses on developing innovative therapeutic approaches using engineered yeast. They are creating living yeast cells that can act as biosensors to detect infections and secrete antibiotics directly where needed, like in wound care. This research aims to improve treatment strategies for various diseases by utilizing synthetic biology techniques to manipulate yeast at the genome level.
synthetic biologyyeast engineeringbiosensorsantibioticsbacterial infectionswound healingtherapeuticscell engineeringdisease treatment
Research Aims
5AIM 01Develop yeast that can sense bacterial infections in wounds.
AIM 02Engineer yeast to secrete different antibiotics based on infection type.
AIM 03Create yeast that responds specifically to the bacteria present in wounds.
AIM 04Utilize synthetic biology to enhance yeast capabilities for therapeutic purposes.
AIM 05Broadly apply engineering techniques to develop yeast for various disease treatments beyond wound infections.
Skills the Lab Values
genetic engineeringcell culturesynthetic biology techniquesCRISPRMolecular cloningantibiotic screeningyeast transformationin vitro assaysbioreactor use
Output against the department
Publications128bottom 29% of dept.153rd of 216
this lab
most publishedleast published
Citations15ktop 34% of dept.74th of 216
this lab
most citedleast cited
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