Washington University in St Louis · NeuroscienceAutoimmune Immunotherapy Unit
Gregory Wu · Saint Louis, Missouri
Research Focus
Dr. Gregory Wu's lab at Washington University focuses on finding innovative immunotherapies for autoimmune diseases like multiple sclerosis. By utilizing advanced CAR-T cell technology, the research aims to specifically target and eliminate T cells that attack the nervous system without compromising the overall immune system. This could lead to more effective treatments for patients with chronic autoimmune conditions.
CAR-T cell therapyautoimmunitymultiple sclerosispeptide MHCIIautoreactive T cells
Research Aims
3AIM 01Improve the efficiency of low affinity T cell deletion in vivo.
AIM 02Test targeting of autoreactive CD4 T cells in mice.
AIM 03Investigate MOGAD patients for MOG-specific T cell frequencies using CAR technology.
Skills the Lab Values
cell cultureanimal modelsflow cytometrygene editingimmunohistochemistryRNA sequencingT cell receptor analysisprotein engineeringin vivo experimentation
Output against the department
Publications123bottom 43% of dept.382nd of 671
this lab
most publishedleast published
Citations5.5kbottom 39% of dept.408th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.