University of North Carolina at Chapel Hill · Mathematics & StatisticsThe Dementia Data Nexus
Hongtu Zhu · Chapel Hill, North Carolina
Research Focus
Dr. Hongtu Zhu's lab focuses on developing advanced tools to better understand Alzheimer's Disease (AD) by using a comprehensive knowledge graph platform. This platform will integrate various types of data, such as genetics, imaging, and clinical information, to identify factors related to the development and risk of dementia. The lab aims to create innovative analytic methods that can assist in discovering new genetic pathways and therapeutic approaches for AD.
Alzheimer's Diseaseknowledge graphneuroimagingmulti-omicsdata integrationdementia researchstatistical geneticsdata science
Research Aims
4AIM 01Construct a dynamic knowledge graph for Alzheimer's Disease from diverse data sources.
AIM 02Develop platforms to harmonize and represent AD-related multi-omics data.
AIM 03Create neuroimaging knowledge graphs for analyzing AD-related imaging data.
AIM 04Analyze large datasets to validate the effectiveness of the integrated knowledge graph in advancing AD research.
Skills the Lab Values
data analysisknowledge graph constructionstatistical modelingmachine learninggenetic data analysisneuroimaging techniquesPython programmingdata visualizationmultivariate analysis
Output against the department
Publications648top 7% of dept.9th of 131
this lab
most publishedleast published
Citations29ktop 18% of dept.24th of 131
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.