Stanford University · BiologyBuckmaster Epilepsy Lab
Paul S. Buckmaster · Stanford, California
Research Focus
Dr. Paul S. Buckmaster's lab focuses on understanding the mechanisms that lead to seizures in patients with temporal lobe epilepsy. By studying certain brain cells known as reelin-positive interneurons in both animal models and human cases, the lab aims to identify their role in seizure development. The ultimate goal is to uncover causes of epilepsy that can improve treatment options for affected individuals.
temporal lobe epilepsyreelin interneuronsepileptogenesisanimal modelsseizure monitoring
Research Aims
5AIM 01Identify the type of reelin interneuron whose loss correlates with seizure frequency.
AIM 02Test the loss of reelin interneurons in a large animal model of temporal lobe epilepsy.
AIM 03Measure synaptic output strength of reelin interneurons.
AIM 04Investigate if reelin-positive interneurons are total molecular layer cells.
AIM 05Determine if the loss of reelin causes seizures.
Skills the Lab Values
immunocytochemistrytelemetric video-EEG monitoringwhole cell recordingpaired recordingbiocytin labeling
Output against the department
Publications116bottom 41% of dept.611th of 1,033
this lab
most publishedleast published
Citations7.7ktop 48% of dept.500th of 1,033
this lab
most citedleast cited
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