Baylor College of Medicine · Microbiology & ImmunologyRotavirus Metabolism Research Lab
Sue Ellen Crawford · Houston, Texas
Research Focus
Dr. Sue Ellen Crawford's lab at Baylor College of Medicine focuses on understanding how rotavirus (RV) infection influences the metabolism of host cells, particularly related to lipid accumulation and degradation of certain proteins. The lab studies the mechanisms by which RV reprograms cellular pathways to enhance its replication and cause severe gastrointestinal issues, especially in young children. Their research aims to uncover reasons behind the life-threatening nature of RV infections and explore potential therapeutic approaches.
rotaviruslipid metabolismintestinal healthviral replicationmalabsorptiondiarrheacellular pathwaysantiviral therapieshost-pathogen interactions
Research Aims
5AIM 01Investigate the molecular mechanisms of NSP2-induced DGAT1 degradation.
AIM 02Explore how RV infection reprograms host lipid metabolism for viral replication.
AIM 03Define interactions between viral proteins and cellular lipid pathways.
AIM 04Evaluate the impact of RV on intestinal cellular functions and malabsorption.
AIM 05Assess the implications of lipid droplet dynamics in RV pathogenesis.
Skills the Lab Values
cell culturemolecular cloningWestern blotPCRimmunofluorescence microscopylipid droplet analysisprotein degradation assaysRNA sequencingbiochemical assays
Output against the department
Publications1bottom 1% of dept.486th of 486
this lab
most publishedleast published
Citations2bottom 2% of dept.476th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.