University of Chicago · GeneticsHe Epigenetics Lab
Xin He · Chicago, Illinois
Research Focus
Dr. Xin He's research lab focuses on understanding how genetic variations affect RNA modifications in immune cells, which may contribute to human diseases. Their work specifically looks at a type of RNA modification called N6-methyladenosine (m6A), which plays a crucial role in regulating RNA processing. By investigating these genetic variants, the lab aims to identify potential therapeutic targets for immune-related disorders.
genetic variationm6A RNA modificationimmune diseasesGWASRNA processingB cellsT cellsimmune phenotypeschromatin-associated RNAsquantitative trait loci
Research Aims
5AIM 01Investigate the effects of genetic variants on N6-methyladenosine modification in immune cells.
AIM 02Map m6A-QTLs in different immune cell types under various conditions.
AIM 03Integrate m6A data with GWAS findings to identify links to immune phenotypes.
AIM 04Study the role of m6A in regulating chromatin-associated RNAs in T cells.
AIM 05Identify potential therapeutic targets based on genetic variants affecting immune disorders.
Skills the Lab Values
PCRcell culturegenome-wide association studies (GWAS)RNA sequencingstatistical analysisbioinformaticsmolecular cloningflow cytometryimmunological assaysdata visualization
Output against the department
Publications194top 44% of dept.113th of 259
this lab
most publishedleast published
Citations9.2kbottom 48% of dept.135th of 259
this lab
most citedleast cited
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