Indiana University-Purdue University-Indianapolis · BiochemistryThe LRRK2 Dynamics Lab
Quyen Quoc Hoang · Indianapolis, Indiana
Research Focus
Dr. Quyen Quoc Hoang's lab at Indiana University Indianapolis focuses on understanding the molecular mechanisms of LRRK2, a protein linked to various diseases including Parkinson's and Alzheimer's. By exploring how mutations affect LRRK2's structure and function, the lab aims to uncover insights that could lead to new treatments. Students in this lab will work with cutting-edge techniques to study protein dynamics and activity.
LRRK2Parkinson's Diseasebiochemical methodscryogenic electron microscopyX-ray crystallographychemical biologyprotein structurekinase activitytherapeutic antibodiesbiologics
Research Aims
3AIM 01Determine the structures and conformational dynamics of LRRK2 using advanced imaging techniques.
AIM 02Investigate the regulatory mechanisms of LRRK2's GTPase and kinase activities.
AIM 03Explore the relationship between LRRK2's conformation and its activity to identify potential therapeutic strategies.
Skills the Lab Values
cryogenic electron microscopyX-ray crystallographyNMR spectroscopyprotein expression and purificationkinase assayshigh-throughput chemical screeningphage displaycell cultureenzyme kineticsGTPase activity assays