Upstate Medical University · PharmacologyCardiac Electrophysiology and Genetics Lab
Nathan R Tucker · Syracuse, New York
Research Focus
Dr. Nathan R. Tucker's lab focuses on understanding how genetic variations contribute to cardiac arrhythmias, which are irregular heartbeats that can be life-threatening. His research aims to link these genetic variations to their biological mechanisms, potentially leading to new treatments. By using advanced techniques like CRISPR and single nucleus RNA sequencing, the lab investigates the genetic and molecular underpinnings of arrhythmias in heart tissue samples, paving the way for innovative therapeutic approaches.
cardiac arrhythmiasgenetic variantsCRISPRsingle nucleus RNA sequencinggene expressionchromatin conformationtranscriptional regulationelectrophysiologytherapeutic development
Research Aims
5AIM 01Identify genetic variants associated with cardiac arrhythmias
AIM 02Investigate the transcriptional misregulation underlying arrhythmia risk
AIM 03Link genotype to gene expression in human heart tissue
AIM 04Use chromatin conformation analysis to find gene targets
AIM 05Facilitate new therapeutic developments for cardiac arrhythmias
Skills the Lab Values
CRISPR/Cas9single nucleus RNA sequencinggene expression profilingchromatin conformation analysiscell cultureelectrophysiology techniquesdata analysis in genomicsmolecular biology techniquesbioinformatics tools
Output against the department
Publications112bottom 30% of dept.321st of 462
this lab
most publishedleast published
Citations6.3kbottom 45% of dept.254th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.