University of North Carolina at Chapel Hill · BiologyHeart Dynamics and Regeneration Lab
Jiandong Liu · Chapel Hill, North Carolina
Research Focus
Dr. Jiandong Liu's lab at the University of North Carolina Chapel Hill focuses on understanding the cellular dynamics and molecular mechanisms involved in heart regeneration and disease. The lab investigates how different types of cells in the heart, including macrophages and fibroblasts, contribute to heart function and tissue repair. Their research aims to uncover new therapeutic strategies for treating heart diseases by exploring how these cells interact and influence heart cell maturation.
heart regenerationmacrophage dynamicscardiomyocyte maturationcardiac fibroblaststranscriptional regulationpost-transcriptional regulationinflammationcell signalingfibrosisRNA-binding proteins
Research Aims
4AIM 01Define the role of inflammatory macrophages in heart regeneration.
AIM 02Investigate the molecular mechanisms of cardiomyocyte maturation.
AIM 03Explore the transformation of cardiac fibroblasts into myofibroblasts.
AIM 04Understand the interactions between different cardiac cell types during regeneration.
Skills the Lab Values
single-cell RNA sequencingcell culture techniquesWestern blottingimmunostaininggene expression analysisCRISPR/Cas9 genome editingmouse modelsflow cytometryRNA splicing analysis
Output against the department
Publications241top 25% of dept.261st of 1,033
this lab
most publishedleast published
Citations6.9kbottom 48% of dept.541st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.