University of California-Irvine · BiologyCenter for Chromatin and Neurodevelopmental Research
Robert F Hunt · Irvine, California
Research Focus
Dr. Robert F. Hunt's lab at UC Irvine focuses on understanding the role of chromatin regulators in neurodevelopmental disorders like epilepsy and autism. The team studies how genetic mutations affect brain development and function, aiming to discover new treatment approaches. By using advanced techniques in genetics, cell biology, and electrophysiology, they explore how to manipulate gene expression to potentially develop targeted therapies.
chromatin regulationneurodevelopmental disordersepilepsyautismgene therapymouse modelsneuronal functionpathologyelectrophysiologypharmacology
Research Aims
5AIM 01Investigate the effects of Chd2 haploinsufficiency on brain development.
AIM 02Analyze electrophysiological changes in neurons with Chd2 mutations.
AIM 03Evaluate the potential of increasing Chd2 expression as a therapeutic strategy.
AIM 04Study the relationship between chromatin regulators and neurodevelopmental disorders.
AIM 05Develop novel treatments for rare neurodevelopmental disorders.
Skills the Lab Values
PCRcell culturemouse modelselectrophysiologywestern blottingimmunohistochemistrygenetic manipulationinduced pluripotent stem cellsbehavioral assayspharmacologic treatment protocols
Output against the department
Publications41bottom 8% of dept.949th of 1,033
this lab
most publishedleast published
Citations1.9kbottom 12% of dept.906th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.