Indiana University-Purdue University-Indianapolis · BiochemistryGenetics of Substance Use Disorders Unit
Howard J Edenberg · Indianapolis, Indiana
Research Focus
Dr. Howard J. Edenberg's lab focuses on understanding the genetic factors that contribute to substance use disorders (SUDs). The lab conducts experiments to identify specific genetic variants that affect gene regulation in brain cells, which could lead to significant insights into the mechanisms behind these disorders. Through innovative high-throughput techniques and computational modeling, the lab aims to create a resource of genetic variants that link to SUD risk, thereby paving the way for future prevention and treatment strategies.
substance use disordersgenetic variantsgene regulationMendelian randomizationhigh-throughput assays
Research Aims
5AIM 01Identify functional genetic variants associated with substance use disorders
AIM 02Evaluate the impact of genetic variants using experimental methods
AIM 03Develop computational models to predict regulatory effects of genetic variants
AIM 04Establish a statistical framework to identify additional contributing genes
AIM 05Create a resource of genetic variants that regulate gene expression in brain cell types
Skills the Lab Values
high-throughput reporter assaysgene expression analysismanual and computational geneticsMendelian randomization methodsmachine learning for genetic modeling
Output against the department
Publications851top 3% of dept.13th of 402
this lab
most publishedleast published
Citations54ktop 4% of dept.16th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.