RFURosalind Franklin University of Medicine and Science · Microbiology & Immunology
Pyroptosis Research Hub
Fabio C Re · North Chicago, Illinois
Research Focus
Dr. Fabio C Re's lab focuses on understanding the role of cellular death processes, particularly pyroptosis, in combating bacterial infections such as melioidosis. By studying how specific proteins in lung cells respond to infections, the research aims to distinguish between protective and harmful immune responses, which could lead to new treatments for bacterial diseases. The lab explores both beneficial and detrimental effects of these responses to improve health outcomes.
melioidosispyroptosisinflammationcaspase-11eicosanoidsbacterial infectionsinnate immunityendothelial cellsepithelial cells
Research Aims
5AIM 01Investigate the protective role of caspase-11 in lung epithelial cells against melioidosis.
AIM 02Assess the production of eicosanoids by lung epithelial cells during infection.
AIM 03Study the detrimental effects of caspase-11 activation in endothelial cells.
AIM 04Examine the role of Tissue Factor in the pathogenesis of melioidosis.
AIM 05Establish the impact of coagulation processes in overall disease severity.
Skills the Lab Values
cell culturemouse modelsWestern blotPCRflow cytometryin vivo experimentationeicosanoid analysispathogen modelingimmunofluorescence
Output against the department
Publications63bottom 17% of dept.404th of 486
this lab
most publishedleast published
Citations8.7ktop 42% of dept.202nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.