University of Pittsburgh-Pittsburgh Campus · BiologyCystic Fibrosis Therapeutics Lab
Daniel C Devor · Pittsburgh, Pennsylvania
Research Focus
Dr. Daniel C Devor's lab at the University of Pittsburgh focuses on understanding how therapies for cystic fibrosis (CF) work and their potential side effects. By studying the modulation of potassium channels affected by CF treatments, the lab aims to uncover how these medications can improve lung function while also addressing adverse events experienced by some patients, such as headaches and anxiety. This research could lead to better therapies for people with CF, enhancing their quality of life.
Cystic fibrosisCFTRpotassium channelsadverse eventsion transport
Research Aims
3AIM 01Define the mechanisms by which CFTR correctors inhibit KCa3.1 and KCa2.x channels and their effects on human bronchial epithelial cell function.
AIM 02Clarify how CFTR correctors potentiate BKCa channels and their impact on cell physiology.
AIM 03Investigate the effects of CFTR corrector-mediated KCa inhibition and BKCa potentiation on vascular reactivity and neuronal action potential firing.
Skills the Lab Values
electrophysiologyin vitro techniqueslive-cell fluorescence imagingpatch-clampmyography
Output against the department
Publications107bottom 37% of dept.650th of 1,033
this lab
most publishedleast published
Citations4.3kbottom 33% of dept.694th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.