University of North Carolina at Chapel Hill · PharmacologyCalabrese Lab
Joseph Mauro Calabrese · Chapel Hill, North Carolina
Research Focus
Professor Joseph Mauro Calabrese's research focuses on understanding the mechanisms of long noncoding RNAs (lncRNAs) in gene regulation. These specialized RNA molecules, which do not code for proteins, play important roles in silencing genes that can affect health and disease, including conditions like Angelman and Rett Syndromes. The lab aims to uncover how these lncRNAs work at the molecular level and how their functions can lead to potential therapeutic discoveries.
long noncoding RNAsgene regulationgene silencingtranscriptional controlepigenetic regulation
Research Aims
5AIM 01Investigate the role of lncRNAs in gene repression
AIM 02Define the relationship between RNA sequence and gene regulation
AIM 03Identify how RNA-binding proteins interact with lncRNAs
AIM 04Explore the implications of lncRNA functions in health and disease
AIM 05Develop computational models to predict lncRNA regulatory roles
Skills the Lab Values
RNA sequencinggene expression analysisRNA processingdata analysis using Pythoncell culture
Output against the department
Publications1bottom 1% of dept.462nd of 462
this lab
most publishedleast published
Citations1bottom 1% of dept.459th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.