University of California-San Francisco · Microbiology & ImmunologyCenter for Engineered T Cell Therapeutics
Kole T Roybal · San Francisco, California
Research Focus
Dr. Kole Roybal's lab at UCSF focuses on developing innovative engineered T cell therapies for cancer treatment, particularly targeting malignant mesothelioma. The lab is pioneering the use of combination antigen sensing technologies to enhance the precision and effectiveness of T cell activation against solid tumors. Additionally, they are working on novel imaging techniques that utilize engineered T cells for better monitoring of tumor response to therapies, contributing to safer and more effective cancer treatments.
T cell therapycancer immunotherapyengineered T cellsSNIPR technologytumor imagingglioblastomamesotheliomaCAR-T cellssynthetic biologybiomarkers
Research Aims
3AIM 01Develop engineered T cell therapies for malignant mesothelioma.
AIM 02Optimize antibody construction for T cell therapy.
AIM 03Establish non-invasive imaging techniques for tracking T cells in tumors.
Skills the Lab Values
T cell engineeringsynthetic biology techniquestumor antigen discoveryin vitro assayslive imagingimmunohistochemistryflow cytometrymolecular cloningreporter gene systemsanimal models for cancer research
Output against the department
Publications91bottom 30% of dept.338th of 486
this lab
most publishedleast published
Citations8.2ktop 43% of dept.211th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.