Icahn School of Medicine at Mount Sinai · NeuroscienceThe Mood Mechanism Lab
Ian S. Maze · New York, New York
Research Focus
The Maze lab conducts innovative research to understand how specific molecular mechanisms in the brain contribute to mental health disorders, particularly mood disorders like depression and conditions such as Down syndrome. By studying post-translational modifications of proteins that affect gene expression, the lab seeks to uncover new therapeutic targets and insights into the regulation of brain function and dysfunction. Their work combines advanced techniques in molecular biology, genetics, and behavioral analysis to address complex neurological challenges.
monoaminergic signalingchromatin regulationmajor depressive disorderDown syndromepost-translational modifications
Research Aims
3AIM 01Investigate the role of histone monoaminylation in mood disorders
AIM 02Examine the impact of chromatin modifications on neurodevelopment in Down syndrome
AIM 03Identify molecular mechanisms that mediate depression susceptibility and response to antidepressants
Skills the Lab Values
PCRcell culturegenetic rescue techniquesbehavioral assays in rodentsbiochemical analysis of protein interactions
Output against the department
Publications109bottom 38% of dept.419th of 671
this lab
most publishedleast published
Citations11ktop 37% of dept.250th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.