University of South Florida · PhysiologyLymphatic Function and Disease Unit
Joshua Paul Scallan · Tampa, Florida
Research Focus
Dr. Joshua Paul Scallan's lab focuses on understanding congenital lymphedema, a genetic condition that causes swelling and infections due to lymphatic vessel dysfunction. Using mouse models, the lab investigates how a specific gene, VEGFR3, affects the structure and function of lymphatic capillaries. This research aims to reveal underlying mechanisms of this disease, potentially leading to new treatments for patients suffering from lymphedema.
LYMPHATIC SYSTEMVEGFR3CONGENITAL LYMPHEDEMACELL SIGNALINGLYMPHATIC JUNCTIONS
Research Aims
3AIM 01Investigate how VEGFR3 affects lymphatic capillary junction remodeling over time.
AIM 02Assess the impact of VEGFR3 loss on interstitial fluid absorption in lymphatic capillaries.
AIM 03Identify and characterize the signaling pathways regulating junction formation in lymphatic vessels.
Skills the Lab Values
Mouse modelsCell culture techniquesLymphatic imagingGene editingProtein analysis
Output against the department
Publications78bottom 17% of dept.236th of 286
this lab
most publishedleast published
Citations3.7kbottom 30% of dept.201st of 286
this lab
most citedleast cited
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