University of Vermont · Microbiology & ImmunologyThali Lab
Markus Thali · Burlington, Vermont
Research Focus
Dr. Markus Thali's lab at the University of Vermont focuses on understanding how the HIV virus spreads in the body, specifically by studying small clusters of infected T cells called syncytia. These syncytia can form as early as the initial stages of infection and may play a significant role in the virus's ability to infect healthy cells. The lab employs advanced imaging techniques and biological assays to explore the movement and behavior of these syncytia, aiming to uncover new strategies to combat HIV.
HIVT cell syncytiaviral transmissionintravital imagingimmunologyHIV pathogenesisproteomicscell behavior
Research Aims
5AIM 01Characterize the motility and migration properties of HIV-1-induced small syncytia.
AIM 02Examine the role of syncytia in the virus transmission dynamics.
AIM 03Investigate host and viral factors that maintain the syncytial compartment.
AIM 04Collaborate with proteomics experts to map the expression profiles of syncytia.
AIM 05Identify potential strategies for intervention based on the findings.
Skills the Lab Values
Flow CytometryLive Cell ImagingIn Vitro Analysis3D Cell ImagingBiochemical AssaysData AnalysisHIV ProteomicsCell Culture
Output against the department
Publications64bottom 18% of dept.400th of 486
this lab
most publishedleast published
Citations6.4kbottom 46% of dept.261st of 486
this lab
most citedleast cited
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