University of Vermont · PhysiologyCaporizzo Lab
Matthew Caporizzo · Burlington, Vermont
Research Focus
Dr. Matthew Caporizzo's lab focuses on understanding diastolic heart disease (DHD), which affects the heart's ability to relax and is a major health issue worldwide. The research investigates how cardiac microtubules contribute to heart stiffness and impaired relaxation in conditions such as hypertension. By examining the molecular mechanisms behind these processes, the team aims to identify potential new therapies that could help treat DHD.
diastolic heart diseasecardiac microtubulesmyocyte mechanicshypertensionheart stiffnessmolecular mechanismstherapeutic targetsfibrosiscardiomyocytes
Research Aims
4AIM 01Investigate the role of cardiac microtubules in myocardial stiffness and diastolic function.
AIM 02Isolate contributions of myocytes and fibrosis to heart muscle mechanics.
AIM 03Utilize an ex-vivo working myocardial slice model to study diastolic performance.
AIM 04Explore the potential of microtubule-targeting therapies for treating diastolic heart disease.
Skills the Lab Values
cell culturemolecular biology techniquestissue preparationmechanical testingimmunofluorescence microscopyprotein analysisdata modelingbiomechanical assaysex vivo heart preparation
Output against the department
Publications76bottom 16% of dept.239th of 286
this lab
most publishedleast published
Citations1.8kbottom 10% of dept.258th of 286
this lab
most citedleast cited
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