University of Minnesota-Twin Cities · PharmacologyFreedman Immunology Lab
Tanya S. Freedman · Minneapolis, Minnesota
Research Focus
Dr. Tanya S. Freedman's lab at the University of Minnesota focuses on understanding the roles of two isoforms of the Lyn kinase, LynA and LynB, in immune signaling and their implications in autoimmune diseases like systemic lupus erythematosus (SLE). The research highlights how these isoforms interact differently in myeloid cells, which are crucial in the immune response. By studying these isoforms, the lab aims to uncover new therapeutic strategies for managing autoimmune conditions, particularly their effects in males and females.
Lyn kinasesystemic lupus erythematosusautoimmunitymyeloid cellsimmune signalingisoform-specific functionsestrogen signalingimmunomodulation
Research Aims
5AIM 01Assess roles of LynA and LynB in ITAM, TLR, and estrogen receptor signaling in both human and murine models.
AIM 02Investigate sex-specific mechanisms of Lyn dysregulation in the progression of lupus.
AIM 03Map isoform-specific kinase-substrate interactions in myeloid cells.
AIM 04Determine the impact of hormonal signaling on lupus development in male and female mice.
AIM 05Explore therapeutic interventions to modulate Lyn signaling pathways in autoimmune disease.
Skills the Lab Values
CRISPRmouse modelscell cultureflow cytometryproteomicsWestern blotconfocal microscopyRNA splicingkinase-substrate mappingsignal transduction
Output against the department
Publications43bottom 4% of dept.443rd of 462
this lab
most publishedleast published
Citations1.1kbottom 5% of dept.441st of 462
this lab
most citedleast cited
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