Cornell University · BiochemistryGene Regulation Dynamics Lab
John T Lis · Ithaca, New York
Research Focus
Dr. John T. Lis's lab at Cornell University focuses on understanding how enhancers and promoters work together to regulate gene expression in the human genome. The team is investigating the role of DNA sequences that control these interactions, which are crucial for understanding how genes are turned on and off in various conditions. By mapping these elements and assessing their functions, they aim to provide insights applicable to both normal biology and diseases.
gene regulationenhancerspromotersDNA sequencingtranscription factors
Research Aims
3AIM 01Define the architecture and function of human enhancers.
AIM 02Test the activity of identified enhancers with various promoters.
AIM 03Explore long-distance interactions between enhancers and promoters.
Skills the Lab Values
GRO/PRO-cap assaychromatin conformation capturemutagenesistranscriptional assaysDNA mapping
Output against the department
Publications276top 24% of dept.98th of 402
this lab
most publishedleast published
Citations36ktop 8% of dept.32nd of 402
this lab
most citedleast cited
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