Indiana University-Purdue University-Indianapolis · PhysiologyBasile Immunology Lab
David P. Basile · Indianapolis, Indiana
Research Focus
Dr. David P. Basile's lab focuses on understanding the role of immune cells in kidney health, particularly how specific cells called Th17 lymphocytes contribute to both acute kidney injury (AKI) and the progression to chronic kidney disease (CKD). The lab studies how high salt intake affects these immune cells and aims to uncover new ways to prevent kidney damage. By exploring different stages of kidney injury and cell interactions, the lab aims to pave the way for innovative therapeutic strategies.
acute kidney injurychronic kidney diseaseTh17 cellsimmune responsehigh salt dietkidney injurycytokine signalingtranscriptional changescell signaling
Research Aims
5AIM 01Investigate the phenotype of Th17 cells at various stages of kidney injury and disease.
AIM 02Determine how high salt diet alters Th17 cell function and cytokine profiles.
AIM 03Explore the role of Th17 cells in immune cell interactions during kidney injury.
AIM 04Assess the impact of inhibiting Th17 pathways on kidney health and disease progression.
AIM 05Identify changes in Th17 cell transcriptional signatures during chronic kidney disease progression.
Skills the Lab Values
FACS imagingmouse modelscell culturegene knockout techniquesPCRWestern blottranscriptional profilingtissue cytometrycalcium signaling assays
Output against the department
Publications210top 31% of dept.89th of 286
this lab
most publishedleast published
Citations8.7ktop 38% of dept.109th of 286
this lab
most citedleast cited
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