University of California-San Diego · ChemistryIKK Signaling and Inflammation Unit
Gourisankar Ghosh · La Jolla, California
Research Focus
Dr. Gourisankar Ghosh's lab at UC San Diego studies the IKK complex, which plays a crucial role in regulating inflammation and immune responses. The lab explores how the structural arrangement of this protein complex influences its activation and function, particularly in relation to inflammatory diseases like arthritis. The research aims to develop new therapeutic strategies that could help treat conditions driven by excessive inflammation.
IKK complexinflammationautoimmunityNF-kB signalingarthritisprotein interactionstherapeutic peptidesdimerizationmolecular biology
Research Aims
4AIM 01Characterize the dimer-dimer interface required for IKK multimerization.
AIM 02Determine the effect of IKK-derived peptides on IKK2 activation in cells and in vivo.
AIM 03Investigate if peptides can reduce systemic inflammation in mouse models.
AIM 04Test the role of specific NEMO mutations in IKK activation.
Skills the Lab Values
protein purificationcell culturemouse modelsWestern blottingpeptide synthesisgenetic mutagenesisin vitro assaysflow cytometrycrystallography
Output against the department
Publications267top 44% of dept.94th of 216
this lab
most publishedleast published
Citations14ktop 36% of dept.78th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.