Case Western Reserve University · PhysiologyCardiac Genomics and Function Lab
Julian Stelzer · Cleveland, Ohio
Research Focus
Dr. Julian Stelzer's research lab at Case Western Reserve University focuses on understanding genetic mutations in the cardiac myosin binding protein C (cMyBP-C) and how these mutations lead to hypertrophic cardiomyopathy (HCM), a condition that can cause heart failure. The lab combines molecular biology, biophysics, and computer modeling to study how specific mutations affect heart muscle function and to develop predictive tools for better treatment strategies. Their goal is to identify which genetic variants pose the greatest risk to patients and to improve clinical outcomes.
hypertrophic cardiomyopathycMyBP-Cgenetic mutationscardiac functionmolecular modeling
Research Aims
3AIM 01Predict how missense mutations in cMyBP-C lead to hypertrophic cardiomyopathy.
AIM 02Test predictions using AAV9 to express mutant cMyBP-C in mice.
AIM 03Develop a data-driven approach to determine effective treatments for cMyBP-C variants.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)molecular biology techniquesanimal models (mouse models)computer modelingdata analysis in biophysics
Output against the department
Publications81bottom 20% of dept.230th of 286
this lab
most publishedleast published
Citations2.4kbottom 17% of dept.237th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.