New York University · BiologyStokes Ion Transport Lab
David L. Stokes · New York, New York
Research Focus
Dr. David L. Stokes' lab focuses on understanding how cells transport ions like potassium and zinc across their membranes. By combining advanced techniques such as cryo-electron microscopy and molecular dynamics simulations, the lab investigates the mechanisms that regulate these transport processes. This research not only provides insights into cellular ionic homeostasis but also has implications for understanding how these processes can be disrupted in diseases.
ion transportKdpFABCYiiPcryo-EMmolecular dynamicsionic homeostasisprotein dynamicsenergeticssubstrate specificitybiophysical assays
Research Aims
5AIM 01Investigate the structural mechanisms of KdpFABC ion transport in bacterial cells.
AIM 02Characterize the Zn2+/H+ antiporter YiiP's energy landscape and transport mechanisms.
AIM 03Analyze the substrate specificity of different ion transporters.
AIM 04Explore the role of protein dynamics in ion transport processes.
AIM 05Develop new methods to visualize and measure the transport mechanisms of ion channels and pumps.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)molecular dynamics simulationssingle-molecule FRETsite-directed mutagenesisbiochemical assaysprotein purificationfunctional characterization assaysenergy landscape mappingstructural biology techniquesdata analysis in biophysics
Output against the department
Publications436top 10% of dept.103rd of 1,033
this lab
most publishedleast published
Citations13ktop 28% of dept.292nd of 1,033
this lab
most citedleast cited
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