University of North Carolina at Chapel Hill · BiologyCardiac Regeneration Lab
Li Qian · Chapel Hill, North Carolina
Research Focus
Dr. Li Qian's lab at the University of North Carolina specializes in innovative strategies to repair heart tissue and improve heart function after injuries like heart attacks. By transforming cardiac fibroblasts into functional heart muscle cells using three specific transcription factors, the lab aims to advance therapies for heart failure, a major health issue. Their research combines cutting-edge techniques like single-cell analysis and mathematical modeling to better understand cardiac cell fate and enhance regenerative medicine approaches.
cardiac repairheart failureinduced cardiomyocytestranscription factorsstem cell biologyregenerative medicinesingle-cell analysismolecular mechanismsepigenetic regulationcardiovascular health
Research Aims
5AIM 01Investigate the molecular mechanisms behind induced cardiomyocyte reprogramming.
AIM 02Enhance the quality and yield of functional heart cells derived from fibroblasts.
AIM 03Test in vivo reprogramming techniques in healthy heart models.
AIM 04Utilize multi-omics approaches to study cellular changes during reprogramming.
AIM 05Explore potential clinical applications for heart disease therapies.
Skills the Lab Values
cell culturemurine modelsgene expression analysissingle cell sequencingepigenetic profilingprotein characterizationflow cytometrymathematical modelingtransfection techniquesin vivo experimentation
Output against the department
Publications28bottom 3% of dept.1,001st of 1,033
this lab
most publishedleast published
Citations261bottom 1% of dept.1,022nd of 1,033
this lab
most citedleast cited
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