University at Buffalo · Microbiology & ImmunologyUroProtect Lab
Chelsie Elizabeth Armbruster · Buffalo, New York
Research Focus
Dr. Chelsie Armbruster's lab focuses on understanding urinary tract infections (UTIs), particularly those associated with catheter use. They explore how certain bacteria interact with the urinary tract and the role of glycosaminoglycans, a protective layer in the bladder, in infection and immune responses. The lab aims to discover new ways to prevent these infections, especially in vulnerable populations, by studying bacterial behavior and the infection process.
urinary tract infectionglycosaminoglycansbacterial interactionscatheter-associated infectionsbiofilm formationpolymicrobial colonizationantimicrobial resistanceurothelial biologyurosepsispathogen fitness
Research Aims
3AIM 01Examine the glycosaminoglycan composition in urinary tracts affected by catheterization.
AIM 02Define the expression and function of bacterial enzymes that degrade glycosaminoglycans.
AIM 03Investigate the effects of polymicrobial interactions on urinary tract infection severity.
Skills the Lab Values
cell culturemouse modelsbiofilm assayspolymerase chain reaction (PCR)genetic sequencingthree-dimensional tissue modelingimmunological assaysmicrobial interaction studiesantibiotic susceptibility testingdata analysis in microbiology
Output against the department
Publications69bottom 20% of dept.387th of 486
this lab
most publishedleast published
Citations2.8kbottom 19% of dept.394th of 486
this lab
most citedleast cited
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