UTMThe University of Texas MD Anderson Cancer Center · Biomedical Engineering
Jiang Immunotherapy Lab
Wen Jiang · Houston, Texas
Research Focus
Dr. Wen Jiang's lab focuses on innovative cancer immunotherapy techniques, particularly using macrophages to target solid tumors like breast cancer and glioblastoma. The research aims to engineer macrophages in vivo to enhance their ability to fight tumors by using mRNA-loaded exosomes, which may simplify current cell therapy methods. This work is significant as it seeks to overcome challenges in traditional CAR T cell therapies, making cancer treatments more effective.
cancer immunotherapychimeric antigen receptormacrophagesmRNA exosomesglioblastomabreast cancersolid tumorstumoricidal therapycell therapy
Research Aims
3AIM 01Investigate how to produce CAR macrophages in vivo using mRNA-loaded exosomes.
AIM 02Assess the dynamics and toxicity of CAR macrophage production.
AIM 03Evaluate the effectiveness of CAR macrophages against breast cancer and glioblastoma.
Skills the Lab Values
mRNA technologyexosome engineeringcell cultureflow cytometryin vivo animal modelstranscriptomic analysisimmunofluorescencegene expression analysisphagocytosis assays
Output against the department
Publications1,276top 3% of dept.16th of 595
this lab
most publishedleast published
Citations34ktop 7% of dept.41st of 595
this lab
most citedleast cited
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