University of Iowa · BiologyCorneal Health and Disease Lab
Rajalekshmy Shyam · Iowa City, Iowa
Research Focus
Dr. Rajalekshmy Shyam's lab at the University of Iowa focuses on understanding Fuchs Endothelial Corneal Dystrophy (FECD), a condition that causes vision loss and currently has no cure. By using a newly developed mouse model that exhibits FECD characteristics, the lab aims to uncover the molecular mechanisms that drive the disease's onset and progression. The ultimate goal is to identify potential therapies and promote corneal health.
Fuchs Endothelial Corneal Dystrophymouse modelcorneal healthubiquitin-proteasome systemcellular signaling
Research Aims
3AIM 01Identify cellular signals involved in the onset of FECD phenotypes.
AIM 02Determine the role of Descemet's membrane changes on corneal endothelial function.
AIM 03Investigate the inactivity of the ubiquitin-proteasome system in developing FECD phenotypes.
Skills the Lab Values
mouse modelsmicroscopymolecular biology techniquescell culturein vivo experimentation
Output against the department
Publications39bottom 7% of dept.961st of 1,033
this lab
most publishedleast published
Citations1.2kbottom 7% of dept.964th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.