Rensselaer Polytechnic Institute · Biomedical EngineeringWang Lab
Chunyu Wang · Troy, New York
Research Focus
Dr. Chunyu Wang's lab at Rensselaer Polytechnic Institute focuses on understanding how variations in the ApoE gene influence the risk of developing Alzheimer's Disease. By exploring the interactions between ApoE and heparan sulfate, a molecule present in the brain, the lab aims to uncover how these binding mechanisms contribute to Alzheimer's pathogenesis. The research combines biochemistry, cell biology, and animal model studies to identify new targets for Alzheimer's treatments.
Alzheimer's DiseaseApoEheparan sulfateisoform interactionprotein binding
Research Aims
3AIM 01Delineate the glycan determinants of ApoE-HS interaction in Alzheimer's Disease.
AIM 02Define isoform specific ApoE-HS interaction at atomic resolution.
AIM 03Study isoform specific ApoE-HS interaction in cellular and animal models.
Skills the Lab Values
molecular biology techniquesanimal modelscell cultureliquid chromatographysurface plasmon resonancemass spectrometrygenetic manipulationbiochemical assaysstructural biology
Output against the department
Publications341top 27% of dept.158th of 595
this lab
most publishedleast published
Citations10ktop 34% of dept.205th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.