Yale University · EngineeringThoracic Aorta Research Lab
Jay D. Humphrey · New Haven, Connecticut
Research Focus
Dr. Jay D. Humphrey's lab at Yale University focuses on understanding diseases of the thoracic aorta, which can lead to serious health issues like aneurysms and dissections. The lab investigates how cells interact with their surrounding structures to maintain healthy tissue, particularly in the context of genetic conditions such as Marfan syndrome. By using advanced computational models and mouse models, the lab aims to uncover the underlying mechanisms of thoracic aortopathy and identify potential new treatment strategies.
thoracic aortaaortopathycell-matrix interactionscomputational modelingMarfan syndromebiomechanicstranscriptional profilingmouse modelsdisease mechanismstherapeutic targets
Research Aims
5AIM 01Investigate the role of cell-extracellular matrix interactions in thoracic aortopathy.
AIM 02Develop computational models to study disease progression in aortic diseases.
AIM 03Quantify the transcriptional profiles that drive biomechanical changes in the aorta.
AIM 04Identify new therapeutic targets based on cellular mechanisms involved in aortic disease.
AIM 05Examine the differential roles of macrophage subpopulations in aortic health and disease.
Skills the Lab Values
cell culturemouse modelsbiomechanical testingcomputational modelinggene expression analysissingle-cell RNA sequencingimmunohistochemistryflow cytometrydata managementstatistical analysis
Output against the department
Publications642top 6% of dept.16th of 278
this lab
most publishedleast published
Citations28ktop 12% of dept.34th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.