University of Florida · BiochemistryUbiquitin Pathways and Drug Discovery Lab
Thomas J. Kodadek · Gainesville, Florida
Research Focus
Dr. Thomas J. Kodadek's research lab at the University of Florida focuses on discovering new small molecules that can interact with proteins, particularly those involved in the Ubiquitin Proteasome System (UPS). His team employs cutting-edge DNA-encoded library technology to identify compounds that can manipulate protein degradation pathways, which are essential for maintaining cellular health. Their innovative approach aims to develop drugs that can enhance the body's ability to remove damaged or misfolded proteins, thereby opening new avenues for treating diseases linked to aging and degeneration.
small moleculesUbiquitin Proteasome Systemprotein degradationchemical probesDNA-encoded libraries
Research Aims
5AIM 01Discover new small molecules that bind to UPS proteins.
AIM 02Develop novel degraders to enhance protein degradation.
AIM 03Optimize screening methods using cell-based assays.
AIM 04Explore the role of UPS dysfunction in aging.
AIM 05Identify ligands for the proteasome's regulatory particle.
Skills the Lab Values
solid-phase synthesiscell cultureprotein-binding assaysfluorescence microscopybiochemical screening
Output against the department
Publications469top 9% of dept.38th of 402
this lab
most publishedleast published
Citations14ktop 34% of dept.138th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.