Icahn School of Medicine at Mount Sinai · BiologySokol Development Lab
Sergei Sokol · New York, New York
Research Focus
Dr. Sergei Sokol's lab studies how cells communicate during the early development of vertebrates, specifically using the model organism Xenopus. They explore the processes that help shape an embryo, looking at how proteins influence cell behavior and organization. This research helps us understand normal development and how diseases like congenital defects and cancer can arise when these processes go wrong.
cell communicationplanar cell polarityXenopus developmentmorhogenesisneural tube defectsextracellular signalingfibroblast growth factorproteomicslive-cell imaging
Research Aims
5AIM 01Investigate how cell-cell communication defines cell fates during embryonic development.
AIM 02Explore the role of the planar cell polarity pathway in cell behavior and movements.
AIM 03Identify the proteins that interact with Diversin and their impact on cell behavior.
AIM 04Examine the influence of fibroblast growth factor signaling on morphogenetic processes.
AIM 05Compare the effects of wild-type and mutated Vangl2 on neural tube folding.
Skills the Lab Values
cell culturelive imagingproteomicsbiochemical assaysmolecular cloninggenetic manipulationmass spectrometrymicroscopydata analysis using Python
Output against the department
Publications173top 38% of dept.394th of 1,033
this lab
most publishedleast published
Citations11ktop 35% of dept.363rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.