Dr. Chen Gu's lab at Ohio State University focuses on understanding how certain ion channels influence both the immune response and neuron function in the central nervous system (CNS). By studying the interactions between T cells and neurons, particularly in conditions like multiple sclerosis, the lab aims to identify new strategies for neuroprotection and repair that could help address inflammatory demyelinating disorders. They employ a variety of advanced techniques to delve into these complex biological processes.

Dr. Amy H Andreotti's lab focuses on understanding the signaling pathways that control T cell activation and differentiation, which are crucial for immune responses to infections and cancer. The lab aims to uncover how variations in T cell receptor (TCR) signaling strength affect gene expression and ultimately influence the behavior of T cells. By exploring the role of the ITK kinase, the lab seeks to improve therapeutic strategies related to autoimmune diseases and cancer.