Dr. Lu Bai's lab at Penn State University focuses on understanding how chromatin structure influences gene regulation. The lab investigates the mechanisms that lead to chromatin accessibility and the organization of chromosomes within the nucleus. This research is significant for unraveling the complexities of gene expression, particularly in relation to human diseases.

Dr. Kent E. Vrana's lab is focused on understanding how cannabis extracts may help relieve chronic pain. By using advanced AI techniques, the lab aims to map out the interactions of various cannabis compounds with biological targets to uncover their therapeutic potential. The research combines computer modeling with laboratory experiments, seeking to validate the effectiveness of these natural products in pain management.

Dr. Song Tan's lab at Penn State is focused on understanding how proteins that modify histones—the proteins that package DNA—regulate gene expression in cells. By studying the structures of these proteins and their interactions with nucleosomes, the lab aims to reveal mechanisms behind gene regulation, particularly in the context of diseases like cancer. This research not only deepens our understanding of fundamental biological processes but also holds potential for developing new therapies targeting gene regulation.

Dr. Joyce Jose's lab at Penn State University focuses on understanding how the Zika virus spreads from mother to fetus, particularly during pregnancy. The lab is exploring a cellular structure known as tunneling nanotubes, which may help the virus transmit between cells in the placenta. By studying these mechanisms, the lab aims to find new ways to prevent serious birth defects linked to Zika virus infections.

Dr. Moriah Szpara's lab at Penn State University focuses on understanding how genetic variation in the herpes simplex virus (HSV) affects disease outcomes in newborns. They investigate why some infants experience severe complications, like infection in the brain or other organs, while others have milder forms. The lab combines genomic analysis of viral samples with laboratory experiments and animal models to uncover links between viral genetics and clinical results, aiming to improve prevention and treatment strategies for high-risk newborns.

Dr. Santhosh Girirajan's lab at Penn State University focuses on understanding how genetic variations lead to different developmental and behavioral outcomes in individuals with complex disorders. The research primarily investigates the effects of a specific chromosome deletion (16p12.1) and how it interacts with other genetic factors to influence susceptibility to conditions such as neurodevelopmental disorders. By studying these interactions in model organisms, the lab aims to shed light on the mechanisms behind phenotypic variability and improve strategies for diagnosis and treatment.

Dr. George Lucian Moldovan's lab studies how cells manage DNA damage during replication. They focus on understanding the mechanisms that prevent and repair damage to DNA, which is crucial for maintaining genomic stability and preventing diseases like cancer. By exploring the roles of specific proteins in repairing DNA, the lab aims to uncover insights that could improve cancer therapies and enhance our understanding of how cells respond to DNA damage.