Dr. Zhen Huang's lab focuses on advancing the diagnosis and treatment evaluation of tuberculosis (TB) using innovative techniques. The lab has developed a novel CRISPR-based assay that can detect Mycobacterium tuberculosis-derived DNA in blood samples, offering a new way to diagnose active and drug-resistant TB cases. This research aims to improve TB management, particularly in areas with high disease burden where traditional diagnostic methods are inadequate.

Dr. Jia Fan's lab focuses on improving the detection and treatment of nontuberculous mycobacterial (NTM) infections using advanced protein analysis techniques. With a particular emphasis on mass spectrometry and computational algorithms, the lab aims to enhance the accuracy of diagnosing specific NTM species and determining their drug resistance. This research is particularly important given the rising incidence of these infections and the need for effective, tailored treatments.

Dr. Christopher J Lyon's lab focuses on improving the diagnosis and management of tuberculosis (TB) in children, particularly those under five years old. The lab is developing a novel blood-based assay that detects proteins from the TB pathogen and the host's immune response using advanced immunoassay technology. By leveraging accessible diagnostic methods, the research aims to enhance the sensitivity and accuracy of TB detection in pediatric patients, especially in resource-limited settings.