Dr. Charles G. Glabe's lab at UC Irvine focuses on understanding the formation and dynamics of amyloid plaques, a key feature of Alzheimer's disease. The research aims to investigate how different types of amyloid deposits are formed by various cell types and their roles in the progression of the disease. By using innovative labeling techniques to track proteins in real-time, the lab hopes to uncover new insights that could guide the development of better therapies for Alzheimer's.

Dr. Selma Masri's research lab focuses on understanding how disruptions in our body's internal clock, known as the circadian clock, can influence the development of colorectal cancer, particularly in younger adults. The lab investigates how these disruptions impact cellular changes in the intestine, metabolism, and immune responses that may contribute to cancer progression. Through innovative mouse models and patient-derived samples, the lab aims to identify new prevention and treatment strategies for colorectal cancer.

Dr. Yilin Hu's lab at UC Irvine focuses on studying nitrogenase, an important enzyme that converts atmospheric nitrogen into ammonia, which is crucial for agriculture and the environment. The team investigates how nitrogenase operates at a molecular level and seeks to improve its expression in bacteria. Their work aims to find innovative applications for nitrogenase that could enhance crop yields and reduce pollution, ultimately contributing to sustainable agricultural practices.

Dr. Christopher C. W. Hughes leads a research lab that focuses on developing advanced models for studying a form of cancer known as peritoneal carcinomatosis, particularly as it relates to colorectal and gastric cancers. The lab aims to create a microfluidic system that closely mimics human tissues to better understand tumor behavior and discover new treatments. Ultimately, their efforts will contribute to improved therapies for patients suffering from these aggressive cancers, addressing significant health disparities related to treatment outcomes.

Marcus Michael Seldin's lab at UC Irvine focuses on understanding how different organs communicate with each other, particularly in the context of diseases like obesity and type 2 diabetes. By combining computational tools with experimental research, the lab aims to identify and validate new endocrine signaling pathways. This innovative integration of bioinformatics and experimental techniques will help uncover the mechanisms of organ communication and their implications in metabolic diseases.

Dr. Ivan Marazzi's lab at UC Irvine focuses on understanding how inflammation affects disease responses during infections and in neurodegenerative conditions like ALS. Their current projects explore how the immune system, particularly certain T cells, influences the severity of COVID-19 and a rare juvenile form of motor neuron disease. The lab aims to develop therapeutic strategies based on their findings to better manage these diseases.

Dr. Peter Kaiser’s lab at UC Irvine studies two major areas: how cells communicate environmental signals through ubiquitin signaling and the reactivation of mutant p53 proteins in cancer. By examining metabolism and its effects on the cell cycle, as well as developing therapies for cancer that target p53, the lab aims to uncover important mechanisms underlying cell growth, disease, and potential treatments.

Roberto Tinoco's lab at UC Irvine focuses on understanding how specific proteins regulate T cell responses during chronic viral infections like HIV and HCV. The research aims to uncover the mechanisms by which T cells become exhausted and explore potential therapies to reinvigorate these immune cells. Overall, the lab seeks to enhance our understanding of T cell behavior and develop new treatment approaches for chronic infections and cancers.