Dr. Stefan Stamm's lab at the University of Kentucky focuses on understanding how specific modifications in RNA, particularly circular RNAs (circRNAs), contribute to Alzheimer's disease. The lab studies how these modifications might lead to the production of proteins that influence the disease process, particularly in relation to tau protein aggregation, a key feature of Alzheimer's pathology. By exploring the mechanisms behind these RNA modifications, the lab hopes to unveil new aspects of Alzheimer's disease that could lead to novel therapeutic strategies.

Dr. Binhua P Zhou's lab focuses on understanding and combating triple-negative breast cancer (TNBC), a highly aggressive form of cancer with poor prognosis. The research aims to investigate how a specific enzyme, nicotinamide N-methyltransferase (NNMT), helps TNBC cells survive under stress and contributes to their spread in the body. By targeting NNMT with specially designed inhibitors, the lab seeks to develop new treatment strategies to improve outcomes for patients with TNBC.