Dr. Carolyn Klinge's lab at the University of Louisville investigates how environmental contaminants, specifically polychlorinated biphenyls (PCBs), affect liver health and metabolism. By examining RNA modifications, particularly N(6)-methyladenosine (m6A), the lab aims to understand their role in metabolic diseases, especially metabolic dysfunction-associated steatotic liver disease (MASLD) and how factors like diet and sex differences influence these processes. Through innovative techniques, the research seeks potential therapeutic targets for improving liver health in the face of environmental exposure.