Dr. Nicolai Doliba's lab at the University of Pennsylvania focuses on understanding the early cellular changes that occur in the progression of Type 1 Diabetes (T1D). The research particularly investigates how alpha cells, responsible for glucagon secretion, function in individuals at high genetic risk for T1D and how their abnormalities might influence the disease's progression. By examining cell signaling pathways and energy metabolism, the lab aims to uncover potential intervention points to delay or prevent T1D development.

Dr. Gregory Bowman's lab at the University of Pennsylvania focuses on understanding the structural role of the apolipoprotein E (ApoE) protein in Alzheimer's disease. By using advanced computer simulations and experimental techniques, the lab aims to uncover the differences between harmful and protective isoforms of ApoE, which could lead to the development of new therapies for Alzheimer's. The research is crucial given the increasing prevalence of Alzheimer's disease as the population ages.

Dr. Kara A. Bernstein's lab at the University of Pennsylvania focuses on understanding how a particular protein complex, called the Shu complex, helps repair DNA damage caused by environmental factors. They study both yeast and human cells to learn about the mechanisms of DNA repair and how disruptions in these processes can lead to cancer. By exploring these fundamental processes, the lab aims to uncover new insights that could help identify individuals at greater risk for cancer due to mutations in the genes involved.

Dr. Ben E. Black's lab at the University of Pennsylvania focuses on understanding how chromosomes are inherited accurately during cell division. They study the centromeres, which are crucial for the proper segregation of chromosomes, to develop artificial chromosomes with potential medical applications. The lab combines structural biology and innovative genome technologies to tackle significant challenges in genome engineering and improve our understanding of genetics.

Dr. Kristen W. Lynch's lab focuses on understanding how a specific protein kinase called TAO2 affects RNA processing and viral replication, particularly during Influenza virus infection. By exploring the interactions and functions of TAO2 in cellular environments, the lab aims to uncover new strategies for controlling viral infections and enhancing our understanding of RNA splicing mechanisms. This work combines genetics, biochemistry, and advanced imaging techniques to make significant implications for viral biology and cellular function.

Dr. Ronen Marmorstein's lab at the University of Pennsylvania focuses on understanding how enzymes involved in metabolism, particularly ATP-citrate lyase (ACLY) and various acetyltransferases, contribute to cancer and other diseases. They study the molecular mechanisms behind how these enzymes are regulated and their role in producing important cellular metabolites. Their work aims to develop new drugs for cancer therapy by targeting these enzymes effectively.

Dr. James Shorter's lab at the University of Pennsylvania is focused on developing innovative RNA-based therapies to combat neurodegenerative diseases like Alzheimer's and ALS. Their research explores how short RNA molecules can prevent harmful changes in a protein called TDP-43, which is involved in many neurodegenerative disorders. By understanding and manipulating the behavior of TDP-43, they aim to create effective treatments that restore normal protein function and protect neurons from degeneration.

Dr. Fange Liu's lab at the University of Pennsylvania focuses on understanding how specific enzymes that modify ribosomal RNA (rRNA) influence the health and functioning of blood stem cells. Particularly, they study a methyltransferase enzyme called DIMT1, which plays crucial roles in both the effectiveness of ribosomes and the expression of genes that are vital for DNA repair and cell survival. The lab aims to uncover how these enzymatic processes affect normal blood cell development and how their dysfunction can lead to disease.