Dr. Eric Wagner's lab at the University of Rochester focuses on understanding how the Integrator Complex, a group of proteins involved in gene regulation, affects the function of neurons. By studying how specific proteins interact within this complex, the lab aims to uncover the molecular mechanisms that regulate neuronal development and function, particularly in the context of neurological disorders. The research holds promise for insights that could improve health outcomes and tackle brain-related diseases.

Dr. Joshua C. Munger's lab studies how human cytomegalovirus (HCMV) interacts with the immune system and how cytokines can help protect against viral infections. The research focuses on understanding the balance between the immune response and viral evasion strategies, particularly investigating how metabolism can be altered to resist infection. The lab aims to uncover novel mechanisms that can be targeted for therapeutic interventions against HCMV, which is a significant cause of disease in immunocompromised patients and can lead to severe congenital disabilities.

Dmitri Ermolenko's lab at the University of Rochester explores how messenger RNA (mRNA) is translated into proteins by the ribosome, a complex molecular machine essential for life. They investigate the structural dynamics of the ribosome and how the shape of mRNA affects its translation efficiency, which is crucial for understanding diseases like cancer and viral infections. Utilizing advanced microscopy and biochemical techniques, the lab aims to uncover the intricacies of protein synthesis and contribute to therapies for viral infections and cancer.

The Mathews lab at the University of Rochester focuses on understanding RNA molecules, which play crucial roles in biology and can be used in pharmaceuticals. They work on developing software and algorithms to predict RNA structures, which are vital for their functions. By studying these structures, the lab aims to contribute to our understanding of disease mechanisms and the development of RNA-based drugs.

Dr. Lynne Maquat's lab at the University of Rochester explores how cells manage their RNA molecules, particularly focusing on a process called nonsense-mediated mRNA decay (NMD). This process helps eliminate faulty RNA that could result from genetic errors and is crucial for maintaining healthy gene expression. The lab's research aims to understand how disruptions in these RNA processes could relate to diseases like fragile X syndrome and various muscle disorders.