Professor Edward H. Egelman's lab at the University of Virginia focuses on understanding the structures of various helical proteins and nucleoprotein polymers using advanced cryo-electron microscopy techniques. The lab studies a range of biological materials, from pathogenic bacterial filaments involved in diseases to viruses that infect extremophiles. Their research not only aims to elucidate fundamental aspects of these structures but also explores potential biomedical applications related to human health.

Dr. Golam Mohi's lab focuses on understanding the molecular mechanisms behind specific blood disorders called myeloproliferative neoplasms and myelodysplastic syndromes. They study how certain gene mutations lead to abnormal blood cell production and increased risk of cancer. The goal is to identify new therapeutic strategies to improve treatment options for these conditions.

Dr. Jeffrey Scott Smith's lab at the University of Virginia studies how aging affects the stability of specific regions of DNA, particularly those that produce ribosomal RNA. The lab focuses on understanding the molecular mechanisms behind DNA damage and repair, especially how certain proteins can both cause and prevent genomic instability. By using yeast and human cell models, the research aims to uncover fundamental insights into how DNA maintains its integrity during the aging process, which could have implications for health and longevity.

The Stukenberg lab at the University of Virginia focuses on understanding how chromosomes are accurately separated during cell division, a process that goes awry in many cancers. They have discovered that a protein complex called the Chromosome Passenger Complex, which includes Aurora B kinase, is crucial for this regulation and can form special structures that help with this accuracy. Their research aims to uncover the molecular mechanisms behind these processes and explore new cancer therapies based on their findings.